TerraD20 - Dark Eden Rising
Over 10,000 years have passed since the Great Fall. Where the earth turned on mankind and nearly wiped the human race out. The land has since changed and rooted itself across oceans now only known as the thousand lakes. Creatures of legend and new more terrifying abominations worst than nightmares run through the vast wilderness. New sub-races and cultures have developed, evolving to meet the dire environment. Cybernetics and magic are widely used and accepted biotechnology has wrought new and devastating arsenals. Large corporations vie for power and control walled cities where the last remaining natural humans or Numan largely exist.
A lone captain of a smuggling vessel has been overthrown and left at sea. His cabin boy barely surviving the mutiny, sets out to find answers with his only companion a razor hound named Y’rune.
After that, take a look at your wiki. There is some more helpful info there.